Copyright © 2002 by the … In conclusion, our genetic analyses directly contradict the widely held belief, especially popular among patients, that DD is a disease of Norse origin. Table 2. See Table 1 for an explanation of the terms used in this study. First, we compared the summed total FST for Norse ancestry informative markers from PoBI in cases and controls in BSSH-GODD. Affections associées. What other conditions predispose to Dupuytren? La maladie de Dupuytren est une maladie évolutive, dont la vitesse d’évolution peut aller de quelques mois à plusieurs années. Part 1: the origin of the disease: the curse of the MacCrimmons: the hand of benediction: Cline's contracture, The Vikings and Baron Dupuytren's disease, Isolated populations as treasure troves in genetic epidemiology: the case of the Basques, Quelques aspects epidemiologiques de la maladie de Dupuytren, Clinical associations of Dupuytren's disease, Epidemiological evaluation of Dupuytren's disease incidence and prevalence rates in relation to etiology, Estimation of levels of gene flow from DNA sequence data, Inference of population structure using dense haplotype data, The fine-scale genetic structure of the British population, A genome-wide association study of Dupuytren disease reveals 17 additional variants implicated in fibrosis, A weighted genetic risk score predicts surgical recurrence independent of high-risk clinical features in Dupuytren's disease, Genetic architecture: the shape of the genetic contribution to human traits and disease. It usually begins with a small lump, called a nodule, in the palm or fingers that is often mistaken for a blister or callus. Dupuytren disease has been referred to as a Viking or Celtic disease, but existed in Europe earlier than the Viking Age8345270 and originated much earlier in prehistory 12015711. The ‘Viking Disease’ The frequency of Dupuytren’s disease is high in many northern European countries where the Vikings settled and thus it is often nicknamed ‘The Viking Disease’. However, it is referred to by commons as Viking disease. ,{i:'fig2-1753193419882851',type:'fig',g:[{m:'10.1177_1753193419882851-fig2.gif',l:'10.1177_1753193419882851-fig2.jpeg',size:'1 MB'}]} En effet les patients atteints de la maladie de Dupuytren notamment serait plus enclin à développer une maladie de Lapeyronie (l’association Dupuytren – maladie de lapeyronie a été retrouvée dans 10 à 15% des cas). However, other evidence indicates a substantial prevalence of DD in countries never affected by Viking invasions, such as Japan, Spain, Ethiopia and India (Dasgupta and Harrison, 1996; Egawa et al., 1990; Gebereegziabher et al., 2017; Guitian, 1988) although clearly, with increasing global migration, admixture of populations is occurring with increasing frequency. By continuing to browse Written informed consent was obtained from all subjects before the study. Maladie de Dupuytren sur l’auriculaire La maladie hépatique alcoolique est une maladie hépatique due à l’abus d’alcool pendant une période prolongée. La maladie de Dupuytren ou contracture de Dupuytren est une fibrose rétractile de l'aponévrose palmaire (une membrane située entre les tendons fléchisseurs et la peau). The PoBI dataset was searched for the statistically most highly associated SNP from each credible set. Les modérateurs de ce forum sont des bénévoles et Dupuytren e.V. The ‘Viking Disease’ The frequency of Dupuytren’s disease is high in many northern European countries where the Vikings settled and thus it is often nicknamed ‘The Viking Disease’. Le fait d'utiliser ce forum sous-entend votre accord à ce sujet. ,{i:'table2-1753193419882851',type:'table-wrap',g:[{m:'10.1177_1753193419882851-table2.gif',l:'10.1177_1753193419882851-table2.jpeg',size:'102 KB'}]} Furthermore, the lack of description of a disease resembling DD in Ancient Greek, Roman, Early Anglo-Saxon or Medieval European writings is further putative evidence of a Nordic origin of the disease (Elliot, 1988). Dupuytren’s disease (DD) is an ancient affliction of unknown origin. Le travail prolongé avec les mains n’est pas responsable de la maladie de Dupuytren. Furthermore, chromosome painting did not find evidence for localized genetic population structure that would be expected around DD-associated SNPs if there were an excess of Norse ancestry. (J Hand Surg 2002;27A:385–390. La maladie de Dupuytren a été décrite par le Baron Dupuytren en 1832. Traitement de la maladie de Dupuytren: 'Dr, quelle est cette dureté sur la paume? Happy Thanksgiving from The Dupuytren Research Group. We conclude that there is no genetic evidence for a ‘Viking origin of Dupuytren’s disease’. Happy Holidays from the Dupuytren Research Group! Data used in this study are available from the European Genome-Phenome Archive (https://ega-archive.org), study numbers EGAS00001000672 and EGAS00001001206, The distribution of genomic FST in both cases and controls closely followed a normal distribution (Figure 1(a)). The 95% confidence intervals for each region overlap, consistent with the notion that DD and Norse ancestry do not cluster together. If DD had been disseminated around Europe by the Norsemen, mention of it in one of these sources would be expected. La maladie de Dupuytren atteint 216 d’entre eux, soit une prévalence de 7,1%. Resume La maladie de Dupuytren est caracterisee par une proliferation de tissu fibreux retractile dans la paume et a la face palmaire des doigts. I’ve counted 113 medical journal articles published since 1985 which associate Dupuytren with the Vikings. Bien que cela ne soit pas totalement certain, cette maladie c’est diffusée surtout en Europe lors des invasions Viking, elle peut prendre des formes variables touchant les mains, les pieds (maladie de Ledderhose) et la verge (maladie de Lapeyronie). Because we were interested in those SNPs that differentiated Orkney from the other populations, all negative FST values were set to zero (Garagnani et al., 2009). If DD were of Norse origin, we would expect that cases would have a higher average total FST than controls. The email address and/or password entered does not match our records, please check and try again. Plater described a stone mason with “contraction of the fingers of the left hand into the palm” [1]. Some society journals require you to create a personal profile, then activate your society account, You are adding the following journals to your email alerts, Did you struggle to get access to this article? This work was supported by the NIHR Biomedical Research Centre, Oxford. Tradition has it that the disease originated with the Vikings, who spread it throughout Northern Europe and beyond as they traveled and intermarried. The local painting for the 21 independent Dupuytren’s GWAS hits was extracted and the frequency for which individuals with each population label shared a most recent haplotype with individuals of each other population was calculated, to form a population co-ancestry matrix for each position in the genome. ENTREZ VOTRE RECHERCHE ET CLIQUEZ ‘ENTER’, S’IL VOUS PLAÎT +34 91 431 00 51; secretaria@drpinal.com; es en fr it ru ar zh-hans +34 91 431 00 51; secretaria@drpinal.com; Accueil; L’Équipe; La Clinique. The evidence for this assertion comes from two main themes. La maladie de Dupuytren est une maladie d'origine inconnue qui touche des tissus (les aponévroses) dont le rôle est de protéger les muscles, les nerfs et les vaisseaux. Simply select your manager software from the list below and click on download. Add to this the known prehistoric cases (like the Egyptian mummy) that are clearly … L’atteinte d’autres membres de la famille, avec des formes de sévérité variable, semble indiquer une origine génétique. Whaley and Elliot (1993) provided an account of four ‘miracles’ from Nordic sources, where a condition resembling DD was alleviated by miracle cures. The medical terminology used for this kind of a hand deformity is Dupuytren's contracture. La maladie de Dupuytren est une maladie qui touche généralement les personnes âgées, mais elle peut apparaître dès l’âge de 40 ans environ. This site uses cookies. mémoire de la … Login failed. NORTHERN or Scottish people are more likely to develop ‘viking’ - or Dupuytren's - disease, which affects one million in the UK. Mesures d`hygiène : tenue de base, précautions. It has been suggested that Dupuytren’s disease has an origin in Norse countries. The mean FST for cases and controls in the British Society for Surgery of the Hand – Genetic Origin of Dupuytren’s Disease dataset. Dupuytren disease has been referred to as a Viking or Celtic disease, but existed in Europe earlier than the Viking Age8345270 and originated much earlier in prehistory 12015711 . For each analysis, FST was calculated between three comparator groups: Orkney vs Wales, Orkney vs South East, and Orkney vs combined Wales and South East. The earliest reference that we found in the medical literature to the condition that ultimately came to be known as Dupuytren’s Disease was a report by Felix Plater in the 17 th century. It is named after Guillaume Dupuytren, who first described the underlying mechanism of action followed by the first successful operation in 1831 and publication of the results in The Lancet in 1834. Le travail manuel n’est pas responsable de la maladie de Dupuytren. The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: DF was supported by an Intermediate Clinical Fellowship from the Wellcome Trust [097152/Z/11/Z]. Dupuytren est le nom du chirurgien qui a décrit la maladie pour la première fois dans les années 1830. La Dystonie . By Lauren Clark PUBLISHED: 13:12, Mon, May 8, 2017 Dupuytren’s disease, Morbus Dupuytren or palmar fibromatosis, sometimes also called DD, Dupuytren’s contracture, or Viking disease, is a chronic disease that produces a benign thickening of the connective tissue, or fascia, of the palm and fingers. Au fur et à mesure que la maladie évolue, ces tissus se rétractent entraînant la … Maladie de Dupuytren La maladie de Dupuytren est une affection de la main caractérisée par une flexion progressive et irréductible de certains doigts. La prédisposition génétique de cette maladie est actuellement établie de façon irréfutable. En 1831, Guillaume Dupuytren était considéré comme le plus grand chirurgien d’Europe ().Sa présentation orale d’un cas de « rétraction des doigts par suite d’une affection de l’aponévrose palmaire » eut un retentissement immédiat en France et en Angleterre et fut à l’origine d’une polémique sur son étiologie et son traitement qui n’est pas encore terminée. Please check you selected the correct society from the list and entered the user name and password you use to log in to your society website. La pathogenèse de la maladie de Dupuytren repose sur leur s tructure tridimensionnelle. Maladie de Dupuytren : causes, symptômes, traitement Maladie de Dupuytren : causes, symptômes, traitementnoté 4.5 - 2 votesL’existence de la maladie de Dupuytren n’est pas très connue. These associations have revealed several novel pathophysiological insights and the risk alleles correlate with recurrence of DD after surgery (Riesmeijer et al., 2019). La maladie de Dupuytren est une maladie d’origine inconnue qui touche des tissus (les aponévroses) dont le rôle est de protéger les muscles, les nerfs et les vaisseaux. L'étiologie est inconnue, l'atteinte est souvent bilatérale, les tendons fléchisseurs des doigts sont indemnes, ce ne sont pas eux qui se rétractent. The authors wish to acknowledge all of the individuals who participated in both studies. It has been suggested that Dupuytren’s disease has an origin in Norse countries. Origin C19: named after the French surgeon Baron Guillaume Dupuytren. Dupuytren's disease: a legacy of the north? We hypothesized that if DD was caused in individuals by having Norse ancestry at these loci, then we would expect that they have an excess amount of local structure, relative to the genome as a whole. Dupuytren's disease is currently called a Viking disease on the assumption that the disease was spread to Europe and the British Isles during the Viking Age of the 9th to the 13th centuries. L'héritage viking (3) : Les Vikings n’ont pas laissé que des vestiges archéologiques. RAPPEL La maladie décrite en 1831 par le Baron Guillaume Dupuytren, chirurgien de l’Hôtel-Dieu de Paris, est génétique et d’origine Viking. It is defined by Dorland as shortening, thickening, and fibrosis of the palmar fascia producing a flexion deformity of a finger. For all comparator groups, the 95% confidence intervals of the difference between means crossed zero meaning there was no significant difference. Dupuytren’s Contracture is known by other names including Viking’s Disease and Baron Dupuytren’s Disease. James Barrie, author of “Peter Pan” had a right contracture thought to be Dupuytren’s, which formed the source material for Captain Hook’s hook. DJL is supported by the Wellcome Trust and Royal Society [WT104125MA]. I have read and accept the terms and conditions, View permissions information for this article. Figure 2. Lore has it that they spread it throughout northern Europe. Compared with previous reports (Whaley and Elliot, 1993), our data provide objective evidence of the lack of Norse origin of the disease. In Orkney vs Wales, the DD-associated set was on the 74th centile; in Orkney vs South East, it was on the 81st centile; and in Orkney vs Wales and South East, it was on the 92nd centile. Download Citation | On Nov 1, 2001, Adrian E. Flatt published The Vikings and Baron Dupuytren's Disease | Find, read and cite all the research you need on ResearchGate window.figureViewer={doi:'10.1177/1753193419882851',path:'/na101/home/literatum/publisher/sage/journals/content/jhsc/2020/jhsc_45_3/1753193419882851/20200212',figures:[{i:'table1-1753193419882851',type:'table-wrap',g:[{m:'10.1177_1753193419882851-table1.gif',l:'10.1177_1753193419882851-table1.jpeg',size:'616 KB'}]} hygiène des mains. Figure 1. ]}. This is contrast to the lactase-associated SNP rs4988235, which as expected shows a highly significant decrease in population-specific haplotype sharing (p < 0.001, Figure 2(b)). Contact us if you experience any difficulty logging in. Table 1. History of Dupuytren's disease Early History of Dupuytren’s Disease and Surgical Treatments. Access to society journal content varies across our titles. the site you are agreeing to our use of cookies. Explanation of terms used in this paper. Dupuytren's disease typically starts at the age of 50 to 60, though even children have been reported to suffer from Dupuytren's disease (example of a 10 year old boy: "Dupuytren's disease in a child: a case report" Dupuytren_child_abstract). We harnessed data from a genome-wide association study of Dupuytren’s disease and the People of the British Isles study to determine evidence for a Norse origin of Dupuytren’s disease. For more information view the SAGE Journals Sharing page. (Classification). The first nickname comes from the belief that the condition originated among the Vikings (inhabitants in Scandinavian countries: Denmark, Norway, and Sweden). Linear regression analysis of hospital episode statistics predicts a large increase in demand for elective hand surgery in England, Effects of vibration on the hand-arm system of miners in India, The early history of contracture of the palmar fascia. LA MALADIE DE DUPUYTREN. Dupuytren's disease is currently called a Viking disease on the assumption that the disease was spread to Europe and the British Isles during the Viking Age of the 9th to the 13th centuries. It is the most common inherited disease of the connective tissue and its prevalence is increasing (Bebbington and Furniss, 2015). We then aggregated these scores across the 35 population labels to investigate possible geographical structure associated with known regions of high Norse ancestry, such as the Highlands of Scotland. 2). La maladie se manifeste surtout après la quarantaine et toucherait 6 fois plus souvent un homme qu’une femme. En règle générale, la quantité d’alcool consommée (volume, fréquence et durée) détermine le risque et la gravité des lésions hépatiques. If DD were of Norse origin, we would expect that the total FST of our disease-associated SNPs would be higher than randomly generated groups of SNPs. Lactase is under positive selection and therefore has much less population-specific haplotype sharing. La Scandinavie et toutes les populations ayant été en contact avec les Vikings, lors des migrations, témoignent encore aujourd'hui du patrimoine génétique qu'ils ont légué au travers de pathologies héréditaires... car la maladie de Dupuytren n'est pas la seule maladie transmise par les vikings. It has been suggested that Dupuytren’s disease has an origin in Norse countries. The first author to suggest an origin and spread of Dupuytren's disease was Early who wrote in 1962, "If one postulates the condition as having arisen in one particular racial group (the Nordic for example) then the variable distribution in other parts of the world might be explained on the basis of migration from that group." Townley, WA, Baker, R, Sheppard, N, Grobbelaar, AO. The recruitment, genotyping, imputation and analysis methods for the BSSH-GODD and PoBI studies have been previously described (Leslie et al., 2015; Ng et al., 2017). The e-mail addresses that you supply to use this service will not be used for any other purpose without your consent. If you have access to a journal via a society or association membership, please browse to your society journal, select an article to view, and follow the instructions in this box. La maladie de Dupuytren ou contracture de Dupuytren est une fibrose rétractile de l'aponévrose palmaire (une membrane située entre les tendons fléchisseurs et la peau). Does Dupuytren by itself affect the risk of having other conditions? Also, Hindocha et al., (2009) stated: ‘Other than the common prevalence of DD in Scandinavia, no objective scientific evidence has been found to date to support and substantiate the “Nordic” origin of the disease’. Why Is Dupuytren's Contracture Called Viking Disease? We then permuted 10,000 random sets of 21 SNPs within the PoBI dataset and calculated the total FST of each of these sets in each of the three comparator groups. It sounds believable. Age distribution of Dupuytren's contracture, influence of gender. Les invasions des Vikings restent le facteur … Selon ce spécialiste de l’appareillage de la main et du membre supérieur, “le doigt à la. Lactase is under positive selection and therefore is expected to show much less population-specific haplotype sharing, and is therefore a positive control in this analysis. La maladie de Dupuytren est une fibrose se présentant au niveau de l’aponévrose moyenne de la paume de la main. Furthermore, Elliot (1988) also comments on the lack of records of DD in the medical writings of the missionaries of Iona, the Roman Church in North Germany and North-East England, or the extensive medical writings from mediaeval Europe. Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube. Create a link to share a read only version of this article with your colleagues and friends. Dupuytren's disease: what dermatologists need to know. La maladie de Dupuytren est caractérisée par une rétraction des doigts secondaire à une prolifération de tissu fibreux rétractile dans l’aponévrose palmaire et ses prolongements dans les doigts. From a literature search, it is proposed that Dupuytren's disease existed in Europe earlier than the Viking Age and originated much earlier in prehistory. ]}. Elle entraîne une rétraction et une flexion progressive et irréductible des doigts. enacademic.com EN. (b,c,d) Comparison of total FST for DD-associated single nucleotide polymorphisms (SNPs; blue line) compared with randomly permuted sets of SNPs. The Papal Benediction sign, with bent ring and small fingers, may have started with a pope with the condition 10050238. Origines et signes de la maladie. window.figureViewer={doi:'10.1177/1753193419882851',path:'/na101/home/literatum/publisher/sage/journals/content/jhsc/2020/jhsc_45_3/1753193419882851/20200212',figures:[{i:'table1-1753193419882851',type:'table-wrap',g:[{m:'10.1177_1753193419882851-table1.gif',l:'10.1177_1753193419882851-table1.jpeg',size:'616 KB'}]} Ethical approval for this study was obtained from: British Society for Surgery of the Hand Genetics of Dupuytren’s Disease (BSSH-GODD) study – Oxfordshire Research Ethics Committee B/09/H0605/65; People of the British Isles study – NRES Committee, Yorkshire and the Humber – Leeds West, UK 05/Q1205/35. We identified the common SNPs between the PoBI dataset and BSSH-GODD dataset and removed multi-allelic SNPs and non-autosomal SNPs, leaving a set of 462,930 SNPs for further analysis. Please read and accept the terms and conditions and check the box to generate a sharing link. We hypothesized that if DD were of Norse origin, the total FST our associated SNPs would be in the top 5% of the ranked total FST for the random permutations of SNPs (nominally p < 0.05). From a literature search, it is proposed that Dupuytren's disease existed in Europe earlier than the Viking Age and originated much earlier in prehistory. Finally, a GRS derived from DD-associated SNPs did not show increased geographical clustering around areas of known high Norse ancestry. Pour des raisons mal connues, ces tissus deviennent épais, se pelotonnent d’abord en boule (les nodules) ce qui entraîne des plis dans la paume ou les doigts. Sign in here to access free tools such as favourites and alerts, or to access personal subscriptions, If you have access to journal content via a university, library or employer, sign in here, Research off-campus without worrying about access issues.

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